Two-Hits to Catastrophic

Two-Hits to Catastrophic

By Janice Staber, MD In 1971, Alfred Knudson, MD, PhD, originally formulated the two-hit hypothesis, which states that most genes require two mutations for a change to occur; this aided the medical community’s understanding of how tumors form. We now know that the...
A Disruptive Innovation?

A Disruptive Innovation?

By Binod Dhakal, MD, MS “I just want to be a normal person, doctor,” Greg said, “but that’s not an option.” Greg, 58 years old, underwent hematopoietic stem cell transplantation (HSCT) for high-risk acute myeloid leukemia (AML) three years ago using cells from his...