Two-Hits to Catastrophic

Two-Hits to Catastrophic

By Janice Staber, MD In 1971, Alfred Knudson, MD, PhD, originally formulated the two-hit hypothesis, which states that most genes require two mutations for a change to occur; this aided the medical community’s understanding of how tumors form. We now know that the...
A Disruptive Innovation?

A Disruptive Innovation?

By Binod Dhakal, MD, MS “I just want to be a normal person, doctor,” Greg said, “but that’s not an option.” Greg, 58 years old, underwent hematopoietic stem cell transplantation (HSCT) for high-risk acute myeloid leukemia (AML) three years ago using cells from his...

Best Donor Choice: It’s in the Eye of the Beholder!

By Basem M. William, MD One of the major leaps in hematopoietic stem cell transplantation (HSCT) is the increasingly successful use of alternative donors, thereby allowing the delivery of a potentially curative transplant to approximately 75 percent of patients who do...
Erythroferrone: A Bone to Pick with Thalassemia

Erythroferrone: A Bone to Pick with Thalassemia

By Alexander Glaros, MD, and Ahmar U. Zaidi, MD If the results of the past five years are any indication, the era of gene therapy is truly at hand, and nearly 100 years after Thomas Cooley first described the skeletal and morphological changes of the disease in a pair...
Aging: Attack of the Clones

Aging: Attack of the Clones

By Binod Dhakal, MD, MS “Aging is not lost youth but a new stage of opportunity and strength.” — Betty Friedan (1921-2006) Blood cells originate from hematopoietic stem cells (HSCs). Adult HSCs are maintained in a quiescent state, a state necessary for preserving the...

Dazed and Con-Bruised?

By Alexander Glaros, MD, and Ahmar U. Zaidi, MD In 1971, then-President Richard Nixon declared drug abuse to be “public enemy number one,” and The War on Drugs was born. It has now been nearly 50 years since the dawn of what proved to be a seismic shift in the focus...

SCD Roundup

By Ahmar U. Zaidi, MD “No conclusions can be drawn from this case. Not even a definite diagnosis can be made,” James Herrick wrote in 1910 about the case of the first known patient in America with sickle cell disease (SCD), Walter Clement Noel. More than one century...

A Run With a Mission

More than 1,500 attendees rose early on a beautiful Sunday morning in Orlando to participate in the 2019 ASH Foundation Run/Walk. ASH is pleased to announce that this year’s sponsors, runners, walkers, and all of their supporters helped the Foun dation raise a total...

The Road to Wisdom: ASH-ASPHO Pediatric Choosing Wisely Collaboration

By Lynn Malec, MD, MSc, and Janice Staber, MD “We are made wise not by the recollection of our past, but by the responsibility for our future.”  – George Bernard Shaw The Choosing Wisely® campaign is an effort led by the American Board of Internal Medicine...

2019 Outstanding Abstract Achievement Awards

ASH is pleased to recognize the following abstract presenters who received the highest ranking in their categories of undergraduate student, medical student, graduate student, resident physician, and post-doctoral fellow. Outstanding Abstract Achievement Award winners...
Philip Greenberg, MD, to Present the 2019 E. Donnall Thomas Lecture

Philip Greenberg, MD, to Present the 2019 E. Donnall Thomas Lecture

Monday at 9:00 a.m., Philip Greenberg, MD, of Fred Hutchinson Cancer Research Center and University of Washington in Seattle will be awarded the 2019 E. Donnall Thomas Lecture and Prize in recognition of his innovative contributions to the development of T-cell...
Supporting Hematology’s Future: The ASH Scholar Award

Supporting Hematology’s Future: The ASH Scholar Award

The ASH Scholar Award is the Society’s longest-standing award program and one of the most highly regarded. For almost three decades, ASH has supported hundreds of fellows and junior faculty in both basic and clinical/translational research by providing partial salary...

Supporting Hematology’s Future: ASH Scholar Award Alums

The ASH Scholar Award is the Society’s longest-standing award program and one of the most highly regarded. For almost three decades, ASH has supported hundreds of fellows and junior faculty in both basic and clinical/translational research by providing partial salary...
The Cure Sickle Cell Initiative: Rewriting an Old Story

The Cure Sickle Cell Initiative: Rewriting an Old Story

The Cure Sickle Cell Initiative (CureSCi; ) was created by the National Heart, Lung, and Blood Institute to accelerate the development of treatments aimed at a genetic- based cure for sickle cell disease (SCD), and ASH has partnered with the Initiative in an effort to...

ASH Announces 2019 Abstract Achievement Awards

Each year, ASH offers merit-based Abstract Achievement Awards in the amount of $500 to select individuals to acknowledge the accomplishments of hematologists-in-training. This year’s Abstract Achievement Awards recognize undergraduate students, medical students,...

ASH Announces Election of Three to Executive Committee

ASH recently announced the election of three new members to its Executive Committee, the governing body of the organization, for terms beginning after the annual meeting. Jane Winter, MD, will serve a one-year term as vice president followed by successive terms as...
ASH Clinical News Celebrates Its Wooden Anniversary

ASH Clinical News Celebrates Its Wooden Anniversary

By David Steensma, MD Editor-in-Chief Designee, ASH Clinical News Yes, there is such a thing. Traditional gifts include wooden picture frames, baskets, and trees. (If you’ve been together with your partner for longer than five years, perhaps you owe him or her a...